The Glucagon-Like Peptide 1 Receptor (GLP-1R), a member of Class B family of G-protein coupled receptors (GPCRs), is an effective target for the treatment of type-2 diabetes, and its incretin peptide and varied peptide mimetics are adopted drugs. Despite remarkable anti-diabetic effects, GLP-1R peptide-based agonists are limited by several disadvantages. Although considerable progress has been […]
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This invention can be a useful synthetic tool for any company / laboratory that is pursuing the synthesis of benzoxaborole-containing targets. Reagents can be commercialized through a chemical supply company making them available for purchase by academic labs and / or companies. This invention currently is in laboratory use. Opportunity The Tomsho Lab has synthesized […]
A new microbiological medium for the detection of Saccharomyces cerevisiae var. diastaticus has been invented at Saint Joseph’s University. Saccharomyces cerevisiae var. diastaticus is a wild yeast contaminant which represents a major beer spoilage threat. Product contamination has led to costly product recalls as infection may lead to off-flavors, over-attenuation, and over-carbonation, thus causing gushing […]
LICENSED: Yeast stain GY7B is a novel, lactic-acid producing yeast capable of acidifying beer to pH3.5 in as little as five days with final attenuation at 2-3 weeks. Typical sour beer production relies upon secondary fermentation with bacteria to develop a complex sour beer flavor profile which can take months or years to fully develop.
Lead Inventor Clyde M. Ofner III, Ph.D Unmet Need A major challenge in cancer chemotherapy is the selective delivery of small molecule anti-cancer agents to cancer cells. Doxorubicin (DOX) is a potent antineoplastic agent that is effective against a wide range of solid tumors and lymphomas but it is also associated with an irreversible cardiomyopathy […]