Autoimmune & Metabolic Disorders

Anti-IDO2 Treatment of Rheumatoid Arthritis and Autoimmune Disorders

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs when the body’s immune system attacks joints, creating debilitating inflammation and pain. Left unchecked this inflammatory condition can permanently damage joint structures, and in some cases, damage the cardiovascular and respiratory systems. This systemic disease affects more than 1.5 million Americans and about 1% of […]

Small molecule allosteric agonists of glucagon-like peptide 1 receptor for treatment of type 2 diabetes

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The Glucagon-Like Peptide 1 Receptor (GLP-1R), a member of Class B family of G-protein coupled receptors (GPCRs), is an effective target for the treatment of type-2 diabetes, and its incretin peptide and varied peptide mimetics are adopted drugs. Despite remarkable anti-diabetic effects, GLP-1R peptide-based agonists are limited by several disadvantages. Although considerable progress has been […]

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