Rabies is a potentially lethal viral infection transmitted primarily by the bite of an infected animal. While mainly prevented by vaccines in the developed world, rabies is endemic in Asia and Africa. Uncontrolled infections cause brain inflammation and manifestation of symptoms is followed by fatal outcomes. Worldwide rabies caused about 17,400 deaths in 2015, about […]
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Assays to measure cell growth and survival assays used in the laboratory have many widely known practical and technical limitations, including non-linearity, high background and cumbersome protocols. In particular, commonly used assays using tetrazolium salts to generate a colored product lack sensitivity and accuracy due to reliance on mitochondrial bioreduction and other factors. The market […]
LIMR researchers have developed a fast, accurate and inexpensive assay, the ThiOX test, that measures the overall thiol redox status of any biological specimen. ThiOX addresses the need for a rapid test to monitor thiol oxidative stress in live cells and tissues. The stability of free thiol groups and disulfide bonds (dithiols) in proteins is […]
Braftide is a synthetic peptide inhibitor that works via a novel dual mechanism of action to inhibit BRAF, a protein that is responsible for cell proliferation, differentiation, and migration. This protein is an integral part of the MAP kinase / ERK signaling pathway. Mutations in BRAF have been identified in melanoma, colorectal cancer, non-Hodgkins lymphoma, […]
The University of the Sciences research team has uncovered CAPER as a novel therapeutic target inside breast cancer cells. CAPER has been shown to be overexpressed in these cancer cells and seems to be helping the cancer thrive and survive. Targeted cancer therapy is becoming a leading approach to cancer treatment and Dr. Jasmin and […]