St. Joseph's University


Phenylalanine Ammonia-Lyase (PAL)-Containing Drug Formulation, Methods of Preparing, Using the Same

Unmet Need Phenylketonuria (PKU) is an inherited disorder that increases levels of phenylalanine in the blood. Phenylalanine is an amino acid obtained through diet and found in all proteins and in some artificial sweeteners. If PKU is not treated, phenylalanine can build up to harmful levels in the body, causing intellectual disability and other serious health […]

Multi-Function Dimeric Constructs for Therapeutic, Drug Delivery, and Imaging Applications

Background Multispecific antibodies represent a paradigm shift in biotherapeutics, moving beyond the traditional “one target, one antibody” model of monoclonal antibodies (mAbs). By enabling a single therapeutic molecule to bind two or more distinct antigens or epitopes, multispecific antibodies can engage complex biological networks with a level of precision unattainable by monospecific mAbs. Among these, […]

Polymer Compositions for Storage and Release of Human Growth Hormone

Unmet Need The inventors believe this invention may address two areas of unmet need. Growth hormone Deficiency: Long-acting dosage form for recombinant human growth hormone (r-hGH) is currently lacking in the market despite the facts that r-hGH was first approved for use by FDA in 1995, the conventional dosage form in the market has a […]

Selective Gq Protein Partial Agonists and Beta-arrestin-biased 5-HT2A Receptor Agonists with Utility in Various Disorders

Unmet Need Serotonergic psychedelics like psilocybin and LSD are known to possess considerable therapeutic potential. They exhibit impressive clinical promise for the treatment of inflammatory disease, substance use disorders, psychiatric disorders, and various neurological conditions. However, there are significant challenges, as these drugs are limited by their hallucinogenic effects, which requires close clinical supervision and […]

Bioprinted PATCH: Poloxamer Alginate Therapeutic Composite Hydrogel

Bandages and gauzes are common devices used in clinical settings to treat an assortment of wounds.  While bandages and gauzes are effective in treating low grade or hemorrhage wounds, they are limited in their success in treating more complex and / or chronic, non-healing wounds. These traditional wound dressings may not adequately fit all parts […]