Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs when the body’s immune system attacks joints, creating debilitating inflammation and pain. Left unchecked this inflammatory condition can permanently damage joint structures, and in some cases, damage the cardiovascular and respiratory systems. This systemic disease affects more than 1.5 million Americans and about 1% of […]
Therapeutics & Prevention
Rabies is a potentially lethal viral infection transmitted primarily by the bite of an infected animal. While mainly prevented by vaccines in the developed world, rabies is endemic in Asia and Africa. Uncontrolled infections cause brain inflammation and manifestation of symptoms is followed by fatal outcomes. Worldwide rabies caused about 17,400 deaths in 2015, about […]
LIMR researchers have developed a fast, accurate and inexpensive assay, the ThiOX test, that measures the overall thiol redox status of any biological specimen. ThiOX addresses the need for a rapid test to monitor thiol oxidative stress in live cells and tissues. The stability of free thiol groups and disulfide bonds (dithiols) in proteins is […]
Hybrid molecular brushes (HMBs) are polymeric constructs comprising a backbone and ide chains of two or more polymers with varying properties. The overall molecular structure of HMBs is governed by steric repulsion among the side chains, and their grafting density on the backbone. HMBs with hydrophilic and hydrophobic fragments have recently come to the forefront, […]
Braftide is a synthetic peptide inhibitor that works via a novel dual mechanism of action to inhibit BRAF, a protein that is responsible for cell proliferation, differentiation, and migration. This protein is an integral part of the MAP kinase / ERK signaling pathway. Mutations in BRAF have been identified in melanoma, colorectal cancer, non-Hodgkins lymphoma, […]